Review

Obesity and kidney disease

Obesity and kidney disease

This is a nice review showing how obesity contributes to kidney disease, particularly in the setting of metabolic syndrome, diabetes and hypertension.

The process starts with glomerular hyperfiltration, and made worse by high sodium and animal protein intake. I suspect that inflammation from visceral adiposity plays a major role too.

It appears that the risk for kidney disease accumulates over time, as prognosis is worse in childhood-onset vs. adult-onset obesity.

GT

AHA Scientific Statement: Biomarkers of Heart Failure

AHA Scientific Statement: Biomarkers of Heart Failure

“Biomarkers from blood can help detect the presence of Heart Failure, determine its severity, assess risk of future events, and guide therapy. The following discussion focuses on biomarkers that are NOT part of the routine clinical evaluation of patients but rather are obtained specifically to further assess prognosis and possibly direct HF therapy. Individual biomarkers are categorized according to their primary pathophysiological mechanism, although multiple pathways may also be involved.”

Circulation

Aging, Diabetes and Cardiovascular Illness

Aging, Diabetes and Cardiovascular Illness

Older adults with diabetes are at higher risk for atherosclerotic cardiovascular disease (ASCVD) than younger adults with diabetes and older adults without diabetes. The rationale to implement ASCVD risk–lowering therapies in older adults with diabetes is compelling.

The variability in health status among older adults is pertinent. Those with robust health are more likely to tolerate and derive benefit from many therapies when compared with those who have more complex health including frailty.

Diabetes Care

Obesity 2017

Obesity 2017

A great review article on the current state of obesity. Increased adiposity or high BMI is a cause or great contributor to multiple of conditions; such as metabolic syndrome, insulin resistance, diabetes, hypertension, high cholesterol, osteoarthritis, impaired renal function, kidney stones, gout and even cancer.