Physiology

Prolactin Resistance

Prolactin Resistance

This is a nice case of prolactin resistance due to loss-of-function variant in the prolactin receptor (PRL-R) gene. A 35 year old female with hyperprolactinemia became pregnant twice, but was unable to lactate. It would take some time before the PRL-R genetic testing becomes available in clinical practice. Nonetheless, the case expands our knowledge of prolactin pathogenesis.

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Night shift work is associated with a higher risk of diabetes

Night shift work is associated with a higher risk of diabetes

Circadian rhythm and cortisol dysregulations have been associated with higher predisposition toward development of diabetes, obesity and metabolic syndrome. Subsequently it is of no surprise that night shift work, a form of circadian and cortisol anomaly, is also shown to raise the risk of diabetes mellitus.

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The 2017 Nobel Prize in Physiology: the genetic clock

The 2017 Nobel Prize in Physiology: the genetic clock

In October 2017, the nobel prize in physiology was awarded to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for discovering molecular and genetic mechanisms of the biological clock.

The Nobel Prize press release is shown below, with slightly modified wording for easier and succinct reading:

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